Histoplasma Antibody, Complement Fixation (HISTCF)

Test Code

LAB2289

Quest Code

938

Alias/See Also

HISTCF

CPT Codes
86698 (x2)

Includes

Yeast Phase Antibody and Mycelial Phase Antibody

Preferred Specimen

1 mL serum in gold top tube

Minimum Volume

0.5 mL

Instructions

For optimal results, collect serum specimen from fasting patients, and maintain aseptically

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic • Grossly icteric

Methodology
Complement Fixation (CF)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Monday-friday

Report Available

5 days

Reference Range

Yeast Phase Ab	<1:8 titer
Mycelial Phase Ab	<1:8 titer

Interpretive Criteria

<1:8	Antibody Not Detected
≥1:8	Antibody Detected

Clinical Significance

This test is used for the diagnosis and prognosis of histoplasma infections. Titers ≥1:32 are highly suggestive of H. capsulatum infection. The CF test is more frequently positive with sera from chronic active pulmonary histoplasmosis than sera from primary active pulmonary disease.

Performing Laboratory

Quest Diagnostics Nichols Institute-Chantilly VA

14225 Newbrook Drive

Chantilly , VA 20151-2228

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.