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Gliadin Antibody (IgA) (GLIIGA)
Test CodeLAB871
Quest Code
11228
Alias/See Also
GLIIGA
CPT Codes
86258
Preferred Specimen
1 mL serum in gold top tube
Minimum Volume
0.5 mL
Other Acceptable Specimens
Plain red top tube
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay (IA)
Setup Schedule
Noon cutoff in dept; 4pm setup; Report by 11pm Monday thru friday
Report Available
3 days
Reference Range
<15.0 U/mL | Antibody not detected | ||
≥15.0 U/mL | Antibody detected |
Clinical Significance
Detection of antibodies to gliadin, one of the major protein components of gluten, is a sensitive assay useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.
Performing Laboratory
Quest Diagnostics - South Region |