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TSI (Thyroid Stimulating Immunoglobulin) (THYSI)
Test CodeLAB746
Quest Code
30551
CPT Codes
84445
Preferred Specimen
1 mL serum collected in plain red top tube
Minimum Volume
0.2 mL
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: Unacceptable
Refrigerated: 21 days
Frozen: 60 days
Refrigerated: 21 days
Frozen: 60 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic • Grossly icteric • Plasma
Methodology
In Vitro Bioassay
Setup Schedule
Tuesday-friday
Reference Range
<140 % Baseline
Clinical Significance
Graves' disease is a classic form of hyperthyroid disease, affecting approximately 0.4% of the population of the United States. It is caused by IgG immunoglobulins, collectively known as thyroid stimulating immunoglobulins (TSI). Patients who are candidates for antithyroid drug therapy may not respond to this treatment when TSI levels are markedly elevated. The determination of TSI can also assist in predicting hyperthyroidism in neonates, due to placental transmission of the immunoglobulins from a mother with hyperthyroidism.
Performing Laboratory
Quest Diagnostics Nichols Institute-Chantilly VA |
14225 Newbrook Drive |
Chantilly, VA 20151-2228 |