Histone Antibodies (HISABY)

Test Code

LAB2524

Quest Code

37056

CPT Codes
83516

Preferred Specimen

1 mL serum in gold top tube

Patient Preparation
Overnight fasting preferred

Minimum Volume

0.3 mL

Other Acceptable Specimens

Plain red top tube

Instructions

Overnight fasting preferred.

Transport Container

Transport tube

Transport Temperature

Refrigerated

Specimen Stability

Room Temperature: 8 HOURS
Refrigerated: 7 DAYS
Frozen: 30 DAYS

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received at room temperature

Methodology
Enzyme Immunoassay (EIA)

Setup Schedule

Monday, Wednesday, and Friday

Reference Range

Value	Explanation of Results
<1.0	Negative
1.0-1.5	Weak Positive
1.6-2.5	Moderate Positive
>2.5	Strong Positive

Clinical Significance

Histone antibody is present in 80-95% of patients with drug-induced Systemic Lupus Erythematosus (SLE), 20-50% of patients with idiopathic SLE, and infrequently in patients with other autoimmune connective tissue diseases.

Performing Laboratory

Quest Diagnostics Nichols Institute-Chantilly VA

14225 Newbrook Drive

Chantilly, VA 20151-2228

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.