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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Fibrinogen Activity, Clauss
Test CodeFIBR
Quest Code
461
CPT Codes
85384
Preferred Specimen
One full 3.2% sodium citrate (light blue-top) tube
Minimum Volume
0.5 mL if as a single test
Other Acceptable Specimens
1 mL platelet-poor anticoagulated plasma collected in a 3.2% sodium citrate (light blue-top) tube, separated and frozen immediately
Instructions
Correct ratio of blood to citrate is critical. Do not overfill or underfill collection tube. Mix by inversion 4 times. Do not pool plasma from multiple tubes.
For non-heparinized patients, maintain specimen at room temperature. Do not uncap. Non-heparinized patients are stable up to 72 hours at room temperature. Heparinized patients stable for 24 hours at room temperature.
If testing cannot be completed within stability limits, centrifuge specimen within 1 hour of collection at 1500 g. Transfer plasma to a transport tube and freeze at -20° C immediately.
For non-heparinized patients, maintain specimen at room temperature. Do not uncap. Non-heparinized patients are stable up to 72 hours at room temperature. Heparinized patients stable for 24 hours at room temperature.
If testing cannot be completed within stability limits, centrifuge specimen within 1 hour of collection at 1500 g. Transfer plasma to a transport tube and freeze at -20° C immediately.
Transport Container
Whole blood: 3.2% sodium citrate (light blue-top) tube
Plasma: Transport tube (frozen)
Plasma: Transport tube (frozen)
Transport Temperature
Room temperature: 3.2% sodium citrate (light blue-top) tube
Frozen: Plasma in transport tube
Frozen: Plasma in transport tube
Specimen Stability
Whole blood (3.2% sodium citrate)
Room temperature: 72 hours (non-heparinized)
Platelet-poor plasma
Frozen -20° C: 30 days
Frozen -70° C: 6 months
Room temperature: 72 hours (non-heparinized)
Platelet-poor plasma
Frozen -20° C: 30 days
Frozen -70° C: 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Clotted
Methodology
Photometry/Optical, Clauss
Setup Schedule
Days or nights Monday-saturday
Report Available
2 days
Limitations
Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect; Heparin (UFH or LMWH): UFH-no effect, LMWH-normal to falsely low; Dabigatran or Argatroban (Thrombin Inhibitors): no effect or falsely low; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.
Reference Range
175-425 mg/dL
Clinical Significance
Fibrinogen is essential for the formation of a blood clot. Deficiency can produce mild to severe bleeding disorders.
Performing Laboratory
| Quest Diagnostics LLC |
| 200 Forest Street 3rd Floor, Suite B |
| Marlborough, MA 01752-3023 |
