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Herpes simplex Virus 1/2, PCR
Test CodeHSVPR
Alias/See Also
HSV DNA, PCR
HSV PCR
HSV PCR
CPT Codes
87529 x2
Preferred Specimen
1.0 mL of CSF
2.0 mL blood
FLOQ swab in UTM
2.0 mL blood
FLOQ swab in UTM
Minimum Volume
0.3 mL of CSF
1.0 mL of whole blood
FLOQ Swab in UTM
1.0 mL of whole blood
FLOQ Swab in UTM
Other Acceptable Specimens
Dermal, eye, nasal, throat, cervix, vagina, urethra, anal/rectal, other genital sources
Transport Container
Sterile screw top container, No additive red top, EDTA (lavendar top), Sodium Citrate (blue top), FLOQ swabs in UTM
Transport Temperature
Refrigerated
Specimen Stability
Room Temperature: 48 hours
Refrigerated: 7 days
Frozen: 7days
Refrigerated: 7 days
Frozen: 7days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Heparinized plasma, CoPan e Swab, other Calcium alginate-tipped swab, wood swab, or transport swab containing gel
Methodology
Real Time Polymerase Chain Reaction (RT PCR)
Setup Schedule
Monday through Friday. Neonatal testing will be performed Monday through Sunday.
Report Available
1 to 2 days
Clinical Significance
DNA testing is analytically more sensitive than culture, especially in patients with encephalitis or meningitis. DNA testing may be useful in diagnosis of infection in neonates. Neonates who have been exposed to HSV can develop disseminated infection and encephalitis. Encephalitis is usually due to HSV I whereas meningitis is usually due to HSV II. DNA testing provides reliable means to define the type.
