Thyrotropin Receptor Antibody, Serum

Test Code

TRAB

Alias/See Also

Antibodies to TSH receptor
Inhibitory Immunoglobulin
Long-Acting Thyroid Stimulator (LATS)
TBII (TSH-Binding Inhibiting Immunoglobulin)
Thyroid-Stimulating Hormone Receptor (TSH Receptor) Antibody
TRAb (Thyrotropin Receptor Antibody)
TSH (Thyroid-Stimulating Hormone) Receptor Binding
TSH Binding Inhibition Index
TSH Receptor (Thyroid-Stimulating Hormone Receptor) Antibody
TSH-Binding Inhibiting Immunoglobulin (TBII)

CPT Codes
83520

Preferred Specimen

2.0 mL of whole blood or 1.0 mL of serum

Minimum Volume

1.0 mL of whole blood or 0.5 mL of serum

Transport Container

SST Tube (gold top) or No Additive Red Top

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated: 7 days
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross Hemolysis

Methodology

Electrochemiluminescence Immunoassay

Setup Schedule

Monday through Saturday

Report Available

Report available within 3 days of receipt at Mayo Medical Laboratories

Reference Range

< or =1.75 IU/L

Clinical Significance

Recommended first-line test for detection of thyrotropin receptor (TSHR) antibodies, and used in the following situations:

-Differential diagnosis of etiology of thyrotoxicosis in patients with ambiguous clinical findings and/or contraindicated (eg, pregnant or breast-feeding) or nondiagnostic thyroid radioisotope scans

-Diagnosis of clinically suspected Graves disease (eg, extrathyroidal manifestation of Graves disease include endocrine exophthalmos, pretibial myxedema, thyroid acropachy) in patients with normal thyroid function tests

-Determining the risk of neonatal thyrotoxicosis in a fetus of a pregnant female with active or past active Graves disease

-Differential diagnosis of gestational thyrotoxicosis versus first trimester manifestation or recurrence of Graves disease

-Assessing the risk of Graves disease relapse after antithyroid drug treatment

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.