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Tropheryma whipplei DNA Qualitative,Real-Time PCR
Test CodeTROW
Quest Code
11352
Alias/See Also
Tropheryma Whipplei
CPT Codes
87798<br>This test is for non-New York patient testing. For New York patient testing on tissue samples, see test code 900262.
Preferred Specimen
> 3 mm3 biopsy, submitted in a sterile, plastic leak-proof container, or
0.7 mL CSF collected in a sterile, plastic leak-proof container, or
0.7 mL whole blood collected in an EDTA (lavender-top) tube, or ACD solution B (yellow-top) tube
0.7 mL CSF collected in a sterile, plastic leak-proof container, or
0.7 mL whole blood collected in an EDTA (lavender-top) tube, or ACD solution B (yellow-top) tube
Minimum Volume
3 mm3 frozen tissue • 0.3 mL CSF or whole blood
Transport Temperature
Biopsy: Frozen
CSF and whole blood: Refrigerated (cold packs)
CSF and whole blood: Refrigerated (cold packs)
Specimen Stability
Biopsy and CSF
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days
Whole blood
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: Unacceptable
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days
Whole blood
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: Unacceptable
Methodology
Real-Time Polymerase Chain Reaction (RT-PCR)
Setup Schedule
Set up: Mon-Sat; Report available: 2-3 days
Reference Range
Not detected
Clinical Significance
Tropheryma whipplei (Whipple's disease) DNA, PCR is a highly sensitive and specific method to detect the presence of Tropheryma whipplei DNA in clinical specimens. The diagnosis of Tropheryma whipplei infection should not rely solely upon the result of a PCR assay. A positive result should be considered in conjunction with clinical presentation and additional established clinical tests. Moreover, this assay cannot differentiate between viable and nonviable organisms. A negative PCR result indicates the absence of Tropheryma whipplei DNA at detectable levels in the samples tested and does not exclude the diagnosis of disease.
Performing Laboratory
Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
33608 Ortega Highway |
San Juan Capistrano, CA 92675-2042 |