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Cardio IQ® Lp-PLA2 Activity
Test CodeLPP
Quest Code
94218
Alias/See Also
Lp-PLA2 ACTIVITY
CPT Codes
83698
Preferred Specimen
1 mL serum
Patient Preparation
Fasting is preferred but not required
Minimum Volume
0.5 mL
Instructions
Process samples by removing or separating serum from red blood cells using standard separation procedures. Recommend to centrifuge and separate samples within four hours of venipuncture as per good laboratory practices.
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 28 days
Refrigerated: 28 days
Frozen -20° C: 43 days
Frozen -70° C: 90 days
Refrigerated: 28 days
Frozen -20° C: 43 days
Frozen -70° C: 90 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Moderate to grossly lipemic • Moderate to grossly icteric
Methodology
Enzymatic Assay (EZA)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Mon-Sat; Report available: 2-3 days
Reference Range
≤ 123 nmol/min/mL
Clinical Significance
Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet activating factor Acetylhydrolase, is an inflammatory enzyme that circulates bound mainly to low density lipoproteins and has been found to be localized and enriched in atherosclerotic plaques. In multiple clinical trials, Lp-PLA2 activity has been shown to be an independent predictor of coronary heart disease and stroke in the general population. Measurement of Lp-PLA2 may be used along with traditional cardiovascular risk factor measures for identifying individuals at higher risk of cardiovascular disease events. Clinical management may include beginning or intensifying risk reduction strategies. The activity assay is an enzyme assay run on an automated chemistry platform.
Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130