Mutated Citrullinated Vimentin (MCV) Antibody

Message

This test is the Quest recommended replacement for 14.3.3 protein.
MCV Antibody is of comparable clinical significance to the 14.3.3 protein when testing for early detection of RA.

Test Code

MCVAB

Quest Code

13238

Alias/See Also

anti-MCV, RA, Rheumatoid Arthritis

CPT Codes
83520

Preferred Specimen

1 mL serum

Minimum Volume

0.5 mL

Instructions

Collection Draw whole blood using red-top tube or serum-separator tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days
Refrigerated: 14 days
Frozen: 6 months

Methodology
Enzyme Linked Immunosorbent Assay (ELISA)

Setup Schedule

Set up: Daily; Report available: 2-4 days

Reference Range

<20 U/mL

Clinical Significance

Anti-mutated citrullinated vimentin (MCV) antibody is one of several specific anti-citrullinated protein antibodies which may be used as a second-line marker of rheumatoid arthritis (RA), in addition to rheumatoid factor and anti-cyclic citrullinated peptide (CCP). MCV antibody is less specific than CCP but has a slightly higher sensitivity and the addition of MCV to CCP adds 5-10% sensitivity for the diagnosis of RA. MCV antibody positivity is also associated with more severe disease and greater radiologic progression.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.