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Antithrombin III Act. 216
Test CodeAT3
Alias/See Also
AT3
CPT Codes
85300
Preferred Specimen
1 mL frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tube
Minimum Volume
1
Instructions
Draw one blue top. Send platelet poor plasma one frozen.
Transport Container
BLUE
Transport Temperature
F
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days
Refrigerated: Unacceptable
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Received thawed • Received refrigerated
Methodology
Chromogenic Substrate
Setup Schedule
Set up: Mon-Fri; Report available: Next day
Limitations
Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect; Heparin (UFH or LMWH): no effect to decrease (UFH may decrease levels physiologically but no assay interference); Dabigatran or Argatroban (Thrombin Inhibitors): may falsely increase; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.
Reference Range
1 day-1 month | 41-108 % normal |
31 days-2 months | 50-120 % normal |
3-5 months | 73-120 % normal |
≥6 months | 80-135 % normal |
Clinical Significance
Aids in the detection of hypercoagulable states associated with venous thrombotic episodes. May be useful in patients who appear to be hyporesponsive to heparin.
Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153