Alkaline Phosphatase, Bone Specific

Test Code
29498

CPT Codes
84075

Preferred Specimen
1 mL serum

Minimum Volume
0.3 mL

Other Acceptable Specimens

Serum separator tube



Instructions
Allow serum samples to clot completely before centrifugation

Transport Container
Plastic screw-cap vial

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 7 days

Refrigerated: 7 days

Frozen: 60 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gross lipemia • Non-serum samples • Grossly icteric

Methodology
Immunoenzymatic

Reference Range
Adult Male  
18-29 Years 8.4-29.3 mcg/L
30-39 Years 7.7-21.3 mcg/L
40-49 Years 7.0-18.3 mcg/L
50-68 Years 7.6-14.9 mcg/L
Adult Female  
18-29 Years 4.7-17.8 mcg/L
30-39 Years 5.3-19.5 mcg/L
40-49 Years 5.0-18.8 mcg/L
50-76 Years 5.6-29.0 mcg/L
Premenopausal  
35-45 Years 5.0-18.2 mcg/L
Pediatric Male (mcg/mL) Female (mcg/mL)
2-24 months* 25.4-124.0 25.4-124.0
25 months-5 Years Not established Not established
6-9 Years 41.0-134.6 41.0-134.6
10-13 Years 43.8-177.4 24.2-154.2
14-17 Years 13.7-128.0 10.5-75.2
*Pediatric data from Int J Biol Markers 1996; 11:159-164.

Clinical Significance
The Bone-Specific Alkaline Phosphatase (BSAP) assay provides a general index of bone formation and a specific index of total osteoblast activity. BSAP and osteocalcin are the most effective markers of bone formation and are particularly useful for monitoring bone formation therapies and antiresorptive therapies.

Performed By
Quest Diagnostics Nichols Institute



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.