Zonisamide [37852Z]

Test Code
ZNSM

CPT Codes
80299

Preferred Specimen
1 mL serum

Minimum Volume
0.5 mL

Other Acceptable Specimens
1 mL plasma collected in: EDTA (lavender-top) tube or sodium heparin (green-top) tube

Instructions
Collect blood in plain red-top tube

Transport Container

Plastic, screw-cap vial

Transport Temperature
Refrigerated

Specimen Stability
Room temperature: 24 hours
Refrigerated: 14 days
Frozen: 45 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gel barrier/serum separator tube

Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Reference Range
10.0 - 40.0 mcg/mL

Clinical Significance
Zonisamide is commonly used as an adjunct together with other conventional anticonvulsants. As multiple drugs are administered, it is important to monitor its level to optimize therapeutic effects, to assure compliance, and to avoid toxicity.

Performed By
Quest Diagnostics Nichols Institute