von Willebrand Comprehensive Panel 2 [15540X]

Test Code

CPT Codes
83520, 85240, 85245, 85246, 85247, 85730

Activated Partial Thromboplastin Time; Factor VIII Activity, Clotting; von Willebrand Factor Antigen; Ristocetin Cofactor Activity; von Willebrand Factor Collagen Binding Assay; von Willebrand Antigen, Multimeric Analysis

Preferred Specimen

1 mL (x4) frozen platelet-poor plasma collected in four 3.2% sodium citrate (light blue-top) tubes

Minimum Volume
0.75 mL (x4)

See individual tests for specific specimen requirements and stabilities.

Platelet poor plasma:
Centrifuge light blue-top tube 15 minutes at approx. 1500 x g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (< 10,000/mcL). Freeze immediately and ship on dry ice.

Storage of whole blood at refrigerated temperatures before processing may lead to cryoprecipitate formation and falsely low Factor VIII and von Willebrand Factor studies.
General drawing instructions: Refer to Quest Diagnostics Nichols Institute Directory of Services under Specimen Collection section, Coagulation Testing, for further information on specimen processing.

Transport Temperature

Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 14 days


Reference Range

See Laboratory Report

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.