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Cutaneous Direct Immunofluorescence
Test Code18899X
CPT Codes
88346, 88350 (x5)
Includes
IgG, IgA, IgM, C3, C5b-9, Fibrinogen
Preferred Specimen
Standard skin biopsy, 4 mm in size, submitted in Michel's fixative (in supplied vial)
Minimum Volume
1 mm
Other Acceptable Specimens
Standard skin biopsy, 4 mm in size, submitted in zeus fixative
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 21 days
Refrigerated: 21 days
Frozen: Unacceptable
Refrigerated: 21 days
Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received frozen
Methodology
Immunoassay (IA)
Setup Schedule
Sets up 5 days a week.
Reference Range
See Laboratory Report
Clinical Significance
These studies contribute to the diagnosis of autoimmune blistering diseases, dermatitis herpetiformis, and IgA vasculitis. Important in the evaluation of other autoimmune and inflammatory skin diseases including non-IgA vasculitides and interface and lichenoid dermatitis/mucositis such as connective tissue disorders, lichen planus, etc. The panel includes the C5b-9 antibody to better distinguish between some forms of Lupus and Dermatomyocitis. Its presence or absence is also critical in the evaluation of other types of connective tissue diseases and many vasculitides.
Performing Laboratory
Ameripath-Institute for Immunofluorescence
895 SW 30th Ave, Suite 101
Pompano Beach, FL 33069-4887