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PRO-PredictRX Metabolites (Prometheus(R) Thiopurine Metabolites)
Test CodePRORX (Quest 37274X)
Alias/See Also
Quest 37274X PROMETHEUS(R)Thiopurine Metabolites (6-MP Metabolites)
Preferred Specimen
5.0 mL Whole Blood Instructions: Collect and transport in Prometheus(R) shipping kit. Ship overnight refrigerated (cold packs). Blood must be kept cool.
Transport Container
EDTA Lavender Top tube
Transport Temperature
Refrigerated
Clinical Significance
Assay includes HPLC Quant for 6-Thioguanine and for 6-Methyl Mercaptopurine. It provides the ability to pharmacologically monitor patients on Azothioprine or 6-MP therapy. Patients' dosage can be individualized based on their metabolism and adjusted for therapeutic effect. The test provides measurement of 6-TG (correlated with clinical response and leukopenia) and 6-MMP (correlated with hepatotoxicity).
