Catecholamines, Fractionated, 24-Hour Urine (without Creatinine)

Test Code

CPT Codes

Dopamine, Epinephrine, Norepinephrine, Total Catecholamines (calculated)

Preferred Specimen
10 mL aliquot from a 24-hour collection preserved with 6N HCl at the start of collection. Unpreserved specimens must be frozen.  

See Urine in the Blood, Urine and Stool section of Specimen Collection and Handling

Minimum Volume
5 mL


24-Hour Urine:
Record 24-hour urine volume on test request form and urine container. Collect 24-hour urine with 25 mL 6N HCl to maintain a pH below 3. Urine with preservative should maintain a pH below 3. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen. Boric Acid and Acetic Acid are no longer acceptable preservatives.

Transport Container
Urine Container, leak-proof

Transport Temperature
Room temperature

Specimen Stability
Room temperature: 7 days
Refrigerated: 30 days
Frozen: 49 days

High Performance Liquid Chromatography (HPLC)

Recent surgery, traumatic injury, upright posture, cold, anxiety, pain, clonidine withdrawal, and concurrent acute or chronic illness may produce elevated results.

Reference Range
3-8 Years 5-41 mcg/24 h
9-12 Years 5-50 mcg/24 h
13-17 Years 12-88 mcg/24 h
>17 Years 15-100 mcg/24 h
3-8 Years 1-7 mcg/24 h
9-12 Years ≤8 mcg/24 h
13-17 Years ≤11 mcg/24 h
>17 Years 2-24 mcg/24 h
3-8 Years 80-378 mcg/24 h
9-12 Years 51-474 mcg/24 h
13-17 Years 51-645 mcg/24 h
>17 Years 52-480 mcg/24 h
Total Catecholamines
3-8 Years 9-51 mcg/24 h
9-12 Years 9-71 mcg/24 h
13-17 Years 13-90 mcg/24 h
>17 Years 26-121 mcg/24 h

Clinical Significance
Fractionated catecholamine measurement is useful in the diagnosis of pheochromocytoma and its differentiation from essential hypertension.

Performing Laboratory
Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.