Cyclic Citrullinated Peptide (CCP) Antibody IgG [11173X]

Test Code
11173X

CPT Codes
86200

Preferred Specimen
1 mL Serum collected in a Red-top tube (no gel)


Minimum Volume
0.5 mL

Other Acceptable Specimens
1 mL Serum collected in Separator tube (SST® - plastic only)


Transport Container
Serum Separator Tube

Transport Temperature
Refrigerated (cold packs)


Specimen Stability
Room temperature: 4 days

Refrigerated: 7 days

Frozen: 30 days

Methodology
Immunoassay (IA)

Limitations
The presence of immune complexes may cause false-positive results due to increased non-specific binding.

Reference Range
Negative <20 units
Weak positive 20-39 units
Moderate positive 40-59 units
Strong positive >59 units


Clinical Significance
A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from other patients than either the perinuclear autoantibody test or the test for rheumatoid factor. Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.

Performed By
Quest Diagnostics Nichols Institute



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.