|
|
| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Platelet Autoantibody, Cell Bound
Test CodePACB
Alias/See Also
Platelet Antibody, Direct
Preferred Specimen
20 mL EDTA whole blood
Minimum Volume
Adults: 10 mL; Pediatrics: 5 mL
Instructions
The patient must have a platelet count >10,000/microliter. Specimen must reach reference lab within 48 hours of collection.
Transport Container
Original collection vial
Transport Temperature
Refrigerated
Specimen Stability
48 hours refirgerated
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimens >48 hours when received at reference lab
Report Available
3-6 days
Reference Range
An interpretive report will be included.
Clinical Significance
Platelet antibodies may be allo- or autoantibodies and may be directed to a wide range of antigenic "targets" on platelet cytoplasmic membranes. Alloantibodies are involved in clinical conditions such as platelet refractoriness, neonatal alloimmune thrombocytopenia, and posttransfusion purpura. In contrast, platelet autoantibodies are involved in idiopathic (autoimmune) thrombocytopenic purpura, the thrombocytopenia associated with systemic lupus erythematosus, and with the thrombocytopenia associated with sepsis (usually bacterial, occasionally fungal). Sometimes platelet autoantibodies can be detected in the patient's serum, but extensive data demonstrate that direct detection of immunologically bound immunoglobulin (usually IgG) is considerably more sensitive for autoantibody detection.
