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Mycophenolic Acid Level
Test CodeMPA
Alias/See Also
CellCept Level
Includes
MPA and MPA glucuronide levels
Preferred Specimen
1 mL serum from plain red top tube
Minimum Volume
0.3 mL
Transport Container
Plastic vial
Transport Temperature
Ambient temperature
Specimen Stability
14 days ambient temperature
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, gross lipemia, gross icterus, collected in SST tubes
Report Available
2-4 days
Reference Range
" MPA: 1.0-3.5 mcg/mL MPA-G: 35-100 mcg/mL
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Clinical Significance
Mycophenolate mofetil (CellCept) is a new immunosuppressive agent useful in organ transplantation. It is approved for use in renal, hepatic, and cardiac transplants. When mycophenolate mofetil enters the blood, it is immediately metabolized to the active drug, mycophenolic acid (MPA), which inhibits inosine monophosphate dehydrogenase and interferes with the de novo pathway of guanosine nucleotide synthesis selectively in lymphocytes. MPA inhibits proliferative responses of T- and B-lymphocytes to both mitogenic and allospecific stimulation. MPA acts in the same fashion as azathioprine, and MPA is suggested as replacement therapy for azathioprine. The drug is deactivated by the hepatic enzyme, uridine diphosphate glucuronosyltransferase to form mycophenolic acid glucuronide (MPA-G).
