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Coagulation Factor VIII Activity Assay
Test CodeF8
Alias/See Also
Factor VIII
Preferred Specimen
1 mL platelet poor sodium citrate plasma
Minimum Volume
0.5 mL
Instructions
Submission of platelet poor plasma is critical to accurate results. Contact laboratory for further information.
Transport Container
Plastic vial
Transport Temperature
Frozen
Specimen Stability
Frozen 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, gross lipemia, gross icterus
Report Available
2-4 days
Reference Range
Adults: 55-200%
Clinical Significance
Congenital factor VIII decrease is the cause of hemophilia A which has an incidence of 1 in 10,000 and is inherited in a recessive sex-linked manner on the X chromosome. Severe deficiency (<1%) characteristically demonstrates as hemarthrosis, deep-tissue bleeding, excessive bleeding with trauma and ecchymoses. Factor VIII may be decreased in von Willebrand disease. Acquired deficiency states also occur.
