Clonazepam Level

Test Code

CLO

Alias/See Also

Klonopin Level

Preferred Specimen

2.5 ml serum from Plain red top tube.

Minimum Volume

2.0 mL

Transport Container

Plastic vial

Transport Temperature

Refrigerated

Specimen Stability

7 days refrigerated

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemplysis, gross lipemia, collected in SST tube

Report Available

2-4 days

Reference Range

Therapeutic concentration: 20-60 ng/mL Toxic concentration: >100 ng/mL

Clinical Significance

Clonazepam is benzodiazepine derivative that is useful alone or as an adjunct in the treatment of the Lennix-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. Clonazepam has been shown to be effective in patients with absence seizures (petit mal) who have failed to respond to succinimide therapy. In some studies, up to 30% of patients have shown a loss of anticonvulsant activity, often within 3 months of administration. In some cases, dosage adjustment may reestablish efficiency.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.