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T & B Cell, QN, Flow Cytometry
Test CodeCD4
Includes
Counts and percentages of CD45, CD3, CD19, CD4, CD8, CD16+CD56 and H/S ratio
Preferred Specimen
3 mL EDTA whole blood
Minimum Volume
1 mL
Instructions
Must arrive to reference lab within 52 hours of collection.
Transport Container
Original collection vial
Transport Temperature
Ambient temperature
Specimen Stability
52 hours
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis, Gross Lipeimia, other anticoagulants
Report Available
2-4 days
Reference Range
See report for normal ranges.
Clinical Significance
Lymphocytes in peripheral blood (circulation) are heterogeneous and can be broadly classified into T cells, B cells, and natural killer (NK) cells. There are various subsets of each of these individual populations with specific cell-surface markers and function. This assay provides absolute (cells/mcL) and relative (%) quantitation for the main categories of T cells, B cells, and NK cells, in addition to a total lymphocyte count (CD45+). Each of these lymphocyte subpopulations have distinct effector and regulatory functions and are maintained in homeostasis under normal physiological conditions. Each of these lymphocyte subsets can be identified by a combination of one or more cell surface markers. The CD3 antigen is a pan-T cell marker, and T cells can be further divided into 2 broad categories, based on the expression of CD4 or CD8 coreceptors. B cells can be identified by expression of CD19, while NK cells are typically identified by the coexpression of CD16 and CD56.
