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Folate, Serum
Test CodeFOL
Alias/See Also
Folic Acid
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Other Acceptable Specimens
Amber vial
Instructions
None
Transport Container
Serum separator tube (SST)
Transport Temperature
Room temperature
Specimen Stability
Refrigerated: 2 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Immunoassay (IA)
Setup Schedule
24/7
Report Available
Same day
Reference Range
0.5-20.0 ng/mL
Clinical Significance
Folic acid deficiency is common in pregnant women, alcoholics, in patients whose diets do not include raw fruits and vegetables, and in people with structural damage to the small intestine. The most reliable and direct method of diagnosing folate deficiency is the determination of folate levels in both erythrocytes and serum. Low folic acid levels, however, can also be the result of a primary vitamin B12 deficiency that decreases the ability of cells to take up folic acid.