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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Estradiol
Test CodeED
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Other Acceptable Specimens
Heparinized plasma
Instructions
None
Transport Container
Serum separator tube (SST)
Transport Temperature
Refrigerated (cool packs)
Specimen Stability
Refrigerated: 2 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Anticoagulants other than heparin
Methodology
Immunoassay (IA)
Setup Schedule
24/7
Report Available
Same day
Reference Range
| Female | ||||||
| Follicular Phase | 30-100 pg/mL | |||||
| Mid-Cycle | 100-400 pg/mL | |||||
| Luteal Phase | 50-150 pg/mL | |||||
| Postmenopausal | 5.0-18.0 pg/mL | |||||
| Male | ≤60 pg/mL | |||||
Clinical Significance
Measuring the circulating levels of estradiol is important for assessing the ovarian function and monitoring follicular development for assisted reproduction protocols. Estradiol plays an essential role throughout the human menstrual cycle. Elevated estradiol levels in females may also result from primary or secondary ovarian hyperfunction. Very high estradiol levels are found during the induction of ovulation for assisted reproduction therapy or in pregnancy. Decreased estradiol levels in females may result from either lack of ovarian synthesis (primary ovarian hypofunction and menopause) or a lesion in the hypothalamus-pituitary axis (secondary ovarian hypofunction). Elevated estradiol levels in males may be due to increased aromatization of androgens, resulting in gynecomastia.
