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Urea Nitrogen (BUN)
Test CodeBUN
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Other Acceptable Specimens
Heparinized plasma
Transport Container
Serum separator tube (SST)
Transport Temperature
REfrigerated (cool packs)
Specimen Stability
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Anticoagulants other than heparin
Methodology
Spectrophotometry (SP)
Setup Schedule
24/7
Report Available
Same day
Reference Range
9-25 mg/dL
Clinical Significance
Urea is the principle waste product of protein catabolism. BUN is most commonly measured in the diagnosis and treatment of certain renal and metabolic diseases. Increased BUN concentration may result from increased production of urea due to (1) diet or excessive destruction of cellular proteins as occurs in massive infection and fevers, (2) reduced renal perfusion resulting from dehydration or heart failure, (3) nearly all types of kidney disease, and (4) mechanical obstruction to urine excretion such as is caused by stones, tumors, infection, or stricture. Decreased urea levels are less frequent and occur primarily in advanced liver disease and in overhydration.