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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Clozapine
Test CodeCLOZAP
Includes
Clozapine and Norclozapine
Preferred Specimen
2 mL serum collected in a red-top tube (no gel)
Minimum Volume
1 mL
Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top) tube, sodium heparin (green-top) tube, or lithium heparin (green-top) tube
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours
Refrigerated: 5 days
Frozen: 30 days
Refrigerated: 5 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gel barrier/Serum separator tube (SST)
Methodology
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Setup Schedule
Mon-fri
Report Available
2-4 days
Reference Range
| Norclozapine | 25-400 mcg/L |
The therapeutic response begins to appear at 100 mcg/L
Refractory schizophrenia appears to require a therapeutic concentration of at least 350 mcg/L (trough, at steady state).
Toxic range: >900 mcg/L
Clinical Significance
Clozapine is an atypical antipsychotic agent. Norclozapine has minimal therapeutic activity.
