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Theophylline
Test CodeTHEO
Alias/See Also
Aminophylline
CPT Codes
80198
Preferred Specimen
Serum (gold top) tube
Minimum Volume
0.5 mL
Other Acceptable Specimens
Lithium Heparin Plasma (green top) tube
Transport Container
Serum (gold top) tube or Lithium Heparin Plasma (green top) tube
Transport Temperature
Room Temperature or Refrigeration
Specimen Stability
Room Temperature - 7 days; Refrigerated - 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Quantity Not Sufficient, EDTA (purple top tube) contamination, IV contamination
Methodology
Colorimetric
Setup Schedule
Daily upon receipt
Report Available
Upon completion of analysis
Limitations
Uremic specimens have shown positive biases of 3–5 μg/mL (17–28 μmol/L) in the therapeutic range for theophylline.
Reference Range
Therapeutic Range: 10 - 20 ug/mL
Clinical Significance
Theophylline is a drug used in the treatment of asthma. Theophylline is an effective bronchodilator. The therapeutic and toxic effects of theophylline are related to the plasma concentrations of the drug. Theophylline measurements are used to monitor patient compliance and therapy and to diagnose potential overdose. Toxic effects include nausea, vomiting, diarrhea, headache, tachycardia, arrhythmias, and convulsions.