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Sickle Cell Screen
Test CodeSCP
CPT Codes
85660
Includes
HGBE if positive
Preferred Specimen
whole blood, EDTA
Minimum Volume
250 uL microtainer or 1 ml lavender top tube
Other Acceptable Specimens
Heparinized Whole Blood
Instructions
All positive results require confirmation by Hemoglobin Electrophoresis
Transport Container
LAV/1
Transport Temperature
ROOM TEMP OR 2-8 DEGREES, C
Specimen Stability
3 weeks at 2-8 degrees C
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
QNS, Clotted or any EDTA sample >24 hours old
Methodology
Differential Solubility
Setup Schedule
24/7
Report Available
24/7
Limitations
Not performed on children <6 months of age
Reference Range
Negative
Clinical Significance
Mendelian inheritance allows S hemoglobin to manifest itself in two manners: (1) as a homozygous condition(S/S) known as sickle cell disease, and (2) as a heterozygous condition where the sickle hemoglobin is present with other hemoglobin, such as hemoglobin A, hemoglobin C, Hemoglobin D, etc. Solubility tests differentiate between sickling and non-sickling hemoglobin but do not distinguish the hemoglobin type.