Estradiol

Test Code

ESTD

CPT Codes
82670

Preferred Specimen

Green

Minimum Volume

0.5 mL

Other Acceptable Specimens

Lithium Heparin Plasma (green top) tube

Transport Container

Serum (gold top) tube or Lithium Heparin Plasma (green top) tube

Transport Temperature

Room Temperature or Refrigeration

Specimen Stability

Room Temperature - 1 day; Refrigerated - 2 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis, turbidity, Quantity Not Sufficient, IV contamination

Methodology
Chemiluminescence

Setup Schedule

Daily upon receipt

Report Available

Upon completion of analysis

Reference Range

Male: 5 - 66 pg/mL

Female:
Follicular Phase:           27 - 161 pg/mL
Pre-Ovulatory Peak:     187 - 132 pg/mL
Luteal Phase                 33 - 201 pg/mL
Post-Menopausal Phase:     5 - 38 pg/mL

Clinical Significance

Estradiol is produced by the adrenals, placenta, and testes and is the principal estrogen secreted by the ovaries. Over 98% of circulating estradiol is bound to serum proteins, principally sex hormone binding globulin (SHBG). Metabolic clearance of estradiol is effected by conversion to estrone, and by hydroxylation and conjugation with sulfate or glucuronide. Estradiol normally exerts negative feedback control on gonadotropin release, however, as estradiol production accelerates with the rapid growth of the dominant follicle, this feedback becomes positive, causing a surge in LH secretion, and ovulation occurs. The measurement of estradiol is useful in assessing a variety of menstrual dysfunctions including delayed puberty, amenorrhoea and menopause.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.