Chronic Lymphocytic Leukemia (CLL) Prognostic Panel, Comprehensive

Test Code

CLLPP

Alias/See Also

LAB12145

CPT Codes
81263, 82232, 88184, 88185 (x2), 88237, 88264, 88271 (x6), 88275 (x3)

Includes

Beta-2-Microglobulin, Serum
Chromosome Analysis, CLL/LPD
Chronic Lymphocytic Leukemia, IgVH Mutation Status, Cell-based
CD38+ CLL cells
FISH, B-Cell Chronic Lymphocytic Leukemia Panel
ZAP-70

Preferred Specimen

Serum and EDTA whole blood and sodium heparin whole blood are required for this panel.
 
Specimen Type: Serum
Collection Container/Type
Preferred: <a href="https://inovalaboratories.testcatalog.org/catalogs/662/files/12246">Serum gel</a>
Acceptable: <a href="https://inovalaboratories.testcatalog.org/catalogs/662/files/12243">Red top</a>
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
 
Specimen Type: Whole Blood EDTA
Collection Container/Type: <a href="https://inovalaboratories.testcatalog.org/catalogs/662/files/12233">Lavender top (EDTA)</a>
Submission Container/Tube: Original tube, do not aliquot
Specimen Volume: 5 mL
Additional Information:
<ul>
<li>Whole blood collected in PPT-Potassium EDTA (white-top) tubes is unacceptable</li>
</ul>
 
Specimen Type: Whole Blood (Sodium Heparin)
Collection Container/Type: <a href="https://inovalaboratories.testcatalog.org/catalogs/662/files/12241">Green top (Sodium heparin)</a>
Submission Container/Tube: Original tube, do not aliquot
Specimen Volume: 16 mL

Minimum Volume

3 mL EDTA whole blood • 10 mL sodium heparin whole blood • 0.5 mL serum

Instructions

See individual tests

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 72 hours
Refrigerated: Unacceptable
Frozen: Unacceptable
 
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Lipemia

Methodology
Culture • Flow Cytometry (FC) • Fluorescence in situ Hybridization (FISH) • Immunoturbidometric • Karyotype • Polymerase Chain Reaction (PCR) • Sequencing
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Mon, Thurs

Report Available

10 days

Reference Range

See Laboratory Report

Clinical Significance

Chronic Lymphocytic leukemia is the most common leukemia in the Western world. The disease is chronic and most patients may not require therapy in the early stage of the disease. However, in some patients the disease can be aggressive and within a year the tumor mass may increase significantly imposing serious health problems to the patient. It is difficult to determine based on clinical presentation which patient will progress faster than the others. Therefore, there is a need to use more accurate prognostic indicator to predict the clinical course of this disease. The recent advances in CLL therapy and biology made it possible to develop new tests and a combination of these tests.

Performing Laboratory

Quest Diagnostics Nichols Institute

14225 Newbrook Drive

Chantilly, VA 20153

Last Updated: February 20, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.