A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Plasminogen Activity

Test Code
PLASN


Alias/See Also

LAB847



CPT Codes
<p>85420</p>

Preferred Specimen

Specimen Type: Platelet-poor plasma

Collection Container/Type: Light blue top (citrate)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: 

  1. Completely fill tube.  Underfilled tubes are unacceptable 
  2. Centrifuge, remove plasma, and centrifuge plasma again.
  3. Aliquot plasma into a plastic vial leaving 0.25 mL in the bottom of centrifuged vial.

For complete instructions, see Platelet Poor Plasma Instructions.

 

Additional Information: Double-centrifuged specien is critical for accurate results as platelet contamination may cause spurious results.



Minimum Volume

0.5 mL



Instructions
Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial(s). Freeze immediately and transport on dry ice.


Transport Temperature
Frozen


Specimen Stability

Room temperature: Unacceptable


Refrigerated: Unacceptable


Frozen: 30 days



Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic • Grossly icteric



Methodology

Chromogenic Substrate



Setup Schedule
Monday, Wednesday, Friday Evening
Report available: Next Day


Report Available

1-3 days



Reference Range
65-176 %


Clinical Significance
Decreased plasminogen activity may be inherited or acquired. Acquired deficiencies may occur with: tranexamic acid and L-asparginase use, disseminated intravascular coagulation (DIC), liver disease, during and after thrombolytic therapy, sepsis, and hyperthyroidism. Plasminogen activity is developmentally regulated reaching adult levels at approximately 6 months of age. As a positive acute phase reactant, increased levels are associated with infection, trauma, surgery, inflammation and malignancy.


Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153


Last Updated: February 20, 2023


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.