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Herpes Simplex Virus, 1 and 2, DNA, Real-Time PCR, CSF
Test CodeHS12C
Alias/See Also
LAB3171
CPT Codes
<p>87529 (x2)</p>
Preferred Specimen
Specimen Type: CSF
Collection Container/Type: Sterile container
Submission Container/Tube: Sterile container
Specimen Volume: 1 mL
Additional Information:
- Specimens collected in heparin-tubes are unacceptable for testing.
- The minimum volume of specimen required for this test, including CSF, is 200 uL (0.2 mL). The sensitivity of this test is based on using this volume of sample. Use of lower amounts may lead to false negative results. Therefore, please be aware that submission of samples with less than 200 uL (0.2 mL) will be rejected for testing.
Minimum Volume
0.3 mL
Instructions
Specimens collected in heparin-tubes are unacceptable for testing.
Please note: The minimum volume of specimen required for this test, including CSF, is 200 uL (0.2 mL). The sensitivity of this test is based on using this volume of sample. Use of lower amounts may lead to false negative results. Therefore, please be aware that submission of samples with less than 200 uL (0.2 mL) will be rejected for testing.
Please note: The minimum volume of specimen required for this test, including CSF, is 200 uL (0.2 mL). The sensitivity of this test is based on using this volume of sample. Use of lower amounts may lead to false negative results. Therefore, please be aware that submission of samples with less than 200 uL (0.2 mL) will be rejected for testing.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Specimens collected in heparin tubes
Methodology
Real-Time PCR
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Daily
Report Available
1 day
Reference Range
HSV-1: Not detected
HSV-2: Not detected
HSV-2: Not detected
Clinical Significance
DNA testing is analytically more sensitive than culture, especially in patients with encephalitis or meningitis. DNA testing may be useful in diagnosis of infection in neonates. Neonates, who have been exposed to HSV, can develop disseminated infection and encephalitis. Encephalitis is usually due to HSV-I, whereas meningitis is usually due to HSV-2. DNA testing provides reliable means to define the Type.
Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153
Last Updated: February 20, 2023