A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Oligoclonal Bands (IgG), CSF

Test Code
OLGSF


Alias/See Also

LAB3291



CPT Codes
<p>83916</p>

Preferred Specimen

Both CSF & serum are required specimens. It is preferred that the collection date and time be the same for both; however, it is acceptable for them to be drawn within 48 hours of each other. If no serum is supplied, the client will be contacted to confirm the order.


 


Specimen Type: Serum


Collection Container/Type


Preferred: Serum gel


Acceptable: Red top


Submission Container/Tube: Plastic vial


Specimen Volume: 1 mL


 


Specimen Type: Spinal Fluid


Collection Container/Type: Sterile container


Specimen Volume: 1 mL


Collection Instructions: 



  • CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.



Minimum Volume

0.5 mL



Instructions
Both CSF & serum are required specimens. It is preferred that the collection date and time be the same for both; however, it is acceptable for them to be drawn within 48 hours of each other. If no serum is supplied, the client will be contacted to confirm the order.

CSF collection tube #4 is preferred. Submitting 4th lumbar puncture collection tube minimizes blood contamination.

Transport temperature: Refrigerate CSF specimens at 2-8°C in sterile plastic CSF vial(s) and send refrigerated (cold packs) to the laboratory or freeze CSF specimens at -20° C and send frozen samples to the laboratory on dry ice.


Transport Temperature
Refrigerated (cold packs)


Specimen Stability

Room temperature: 8 hours


Refrigerated: 5 days


Frozen: 14 days


 


Transport temperature: Refrigerate CSF specimens at 2-8°C in sterile, plastic CSF vial(s) and send refrigerated (cold packs) to the laboratory OR freeze CSF specimens at -20°C and send frozen samples to the laboratory on dry ice.



Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature



Methodology

Isoelectric Focusing (IEF)



Setup Schedule
Set up: Sun-Fri; Report available: 4-6 days


Report Available

4-6 days



Reference Range
Absent


Clinical Significance
Oligoclonal bands are present in the CSF of more than 85% of patients with clinically definite multiple sclerosis (MS). To distinguish between oligoclonal bands in the CSF due to a peripheral gammopathy and oligoclonal bands due to local production in the CNS, serum and CSF should be tested simultaneously. Oligoclonal bands can however be observed in a variety of other diseases, e.g., subacute sclerosing panencephalitis, inflammatory polyneuropathy, CNS lupus, and brain tumors and infarctions.


Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153


Last Updated: February 17, 2023


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.