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Hemoglobinopathy Profile

Test Code
HGPPR


CPT Codes
83020, 83051

Includes
Hemoglobinopathy Evaluation without Hemogram
Hemoglobin, Free, Plasma

(Hemoglobin A; Hemoglobin F; Hemoglobin A2 (Quant); Hemoglobin A2 Prime; Hemoglobin S; Hemoglobin C; Hemoglobin D; Hemoglobin G; Hemoglobin Lepore; Hemoglobin E; Hemoglobin O-Arab; Hemoglobin Barts; Variant Hemoglobin; Sickle Cell Screen; Hemoglobin F, Differential Staining)


Preferred Specimen

Patient Preparation: 

Specimen Type: Whole blood EDTA AND Plasma Sodium Heparin

Collection Container/Type: Lavender top (EDTA) AND Green top (Sodium heparin)

Submission Container/Tube: Lavender top (EDTA) tube AND Plastic vial

Specimen Volume: 5 mL whole blood & 1 mL plasma

Collection Instructions: 

  1. Centrifuge sodium heparin tube within 1 hour of collection.  Transfer plasma to a plastic vial.
  2. Send lavender samples in original collection tube, do not aliquot.

Additional Information:

  1. If only normal Hemoglobins are detected, the results will be reported within 24 hours.
    However, if any abnormal Hemoglobins are present that require additional testing, turnaround time may take as long as 5 days.
    Specimens for Hemoglobin by HPLC are stable for 7 days at refrigerator temperature. However, if Hemogram is needed for accurate interpretation, the Hemogram portion is only stable for 3 days from the time of collection at refrigerator temperature.


Minimum Volume

4 mL Whole Blood & 0.2 mL plasma



Specimen Stability

Room temperature: 7 days


Refrigerated: 7 days


Frozen: Unacceptable



Methodology

High Performance Liquid Chromatography (HPLC) Colorimetry (C) Electrophoresis

High Performance Liquid Chromatography

Solubility



Setup Schedule

Hemoglobin A2, Quantitative: Tuesday - Sunday


Hemoglobin, Free, Plasma: Tuesday - Saturday PM


Hemoglobinopathy Evaluation: Monday - Friday



Report Available

1 - 3 days



Reference Range
See individual tests


Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153


Last Updated: February 17, 2023


The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.