| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Cyclic Citrullinated Peptide (CCP) Antibody (IgG)
Test CodeCCPIG
Alias/See Also
LAB851
CPT Codes
<p>86200</p>
Preferred Specimen
Specimen Type: Serum
Collection Container/Type
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Minimum Volume
0.5 mL
Transport Container
Plastic screw-cap vial
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Gross lipemia • Plasma
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Tues-Sat a.m.; Report available: Next day
Report Available
Next day
Limitations
The presence of immune complexes may cause false-positive results due to increased non-specific binding.
Reference Range
| Negative | <20 Units | ||||
| Weak positive | 20-39 Units | ||||
| Moderate positive | 40-59 Units | ||||
| Strong positive | >59 Units | ||||
Clinical Significance
A synthetic circular peptide containing citrulline called CCP IgG (cyclic citrullinated peptide) has been found to be better at discriminating Rheumatoid Arthritis patients from patients with other diseases such as hepatitis C infection. Rheumatoid Arthritis Classification Criteria include CCP IgG Antibody, rheumatoid factor, C-reactive protein and erythrocyte sedimentation rate (ESR). Approximately 70% of patients with Rheumatoid Arthritis are positive for Anti-CCP IgG, while only about 2% of random blood donors and disease controls subjects are positive.
Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153
Last Updated: February 17, 2023