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Alkaline Phospatase
Test CodeALP
Alias/See Also
Epic: LAB112
CPT Codes
84075
Preferred Specimen
Specimen Type: Serum
Collection Container: Serum gel
Specimen Volume: 3 mL
Minimum Volume
0.10 mL
Instructions
Centrifuge and separate cells after clot formation and within 4 hours of collection
Transport Container
Plastic vial
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 2 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Unlabeled, mislabeled, wrong tube type, hemolysis, QNS
Methodology
Para-nitrophenol Phosphate
Setup Schedule
Daily
Report Available
Same day
Reference Range
| 0 - 1 year 110 – 300 U/L |
1 - 4 years 145 - 320 U/L |
4 - 7 years 150 - 380 U/L |
| 7 - 10 years 175 - 420 U/L |
10 - 12 years M 135 – 530 U/L F 130 - 560 U/L |
12 - 14 years M 200 – 495 U/L F 105 – 420 U/L |
| 14 - 16 years M 130 - 525 U/L F 70 – 230 U/L |
16 - 20 years M 65 - 260 U/L F 50 – 130 U/L |
20 - 150 years M 38 – 106 U/L F 37 – 106 U/L |
Clinical Significance
Human alkaline phosphatase consists of a group of at least 5 tissue-specific isoenzymes which catalyzes the hydrolysis of phosphate mono-esters at an alkaline pH. Alkaline Phosphatase is used to check for bone or liver disease. In addition to liver, bile duct, or gallbladder dysfunction, an elevated serum level can be due to rapid growth of bone and congestion or obstruction of the biliary tract. Decreased serum alkaline phosphatase may be due to zinc deficiency, hypothyroidism, folic acid deficiency, excess Vitamin D intake, hypophosphatasia, and celiac disease, malnutrition with low protein, pernicious anemia and vitamin B6 insufficiency. A variety of disease states result in the release of increased quantities of alkaline phosphatase into the blood.
Performing Laboratory
Inova Laboratories
2832 Juniper Street
Fairfax, VA 22031
Last Updated: April 11, 2023
Last Review: N. Wolford, March 3, 2023