Alpha-1-Antitrypsin

Test Code

A1AT

Alias/See Also

Epic: LAB810

Alpha 1 Antitrypsin
Anti-Alpha-1-Trypsin
Prolastin
A1A
AAT (Alpha-1-Antitrypsin)
Alpha-1-Antitrypsin Reflex
AAT

CPT Codes
82103

Preferred Specimen

Specimen Type: Serum
Collection Container: Red top
Specimen Volume: 3.0 mL

Minimum Volume

0.25 mL

Instructions

Centrifuge and separate cells after clot formation and within 4 hours of collection

Transport Container

Plastic vial

Specimen Stability

Room temperature: 3 months
Refrigerated: 5 months
Frozen: 3 months

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Unlabeled, mislabeled, wrong tube type, hemolyzed, QNS, exceeds specimen stability requirements.

Methodology

Turbidimetric

Setup Schedule

Daily

Report Available

Same day

Limitations

No prozone interference for undiluted samples up to 1260mg/dL of A1-AT. Prozone interference has not been validated past 1260mg/dL.

Reference Range

84 - 200 mg/dL

Clinical Significance

A1-AT is a protein synthesized in the liver. Deficiency in adults results in pulmonary emphysema and hepatic diseases. Among children, severe deficiency most frequently presents as liver disease, cholestasis, and cirrhosis. A1-AT is also an acute-phase protein and its concentration increases several fold in the case of acute or chronic active inflammation. Patients may have falsely normal levels during acute illness.

Performing Laboratory
Inova Laboratories
2832 Juniper Street
Fairfax, VA 22031

Last Updated: March 3, 2023
Last Review: N. Wolford, March 3, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.