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Haptoglobin
Test CodeHAPT
Alias/See Also
Epic: LAB89
Preferred Specimen
Specimen Type: Serum
Collection Container: Serum gel
Specimen Volume: 3 mL
Minimum Volume
0.25 mL
Other Acceptable Specimens
Specimen Type: Plasma
Collection Container: Green top (Lithium heparin)
Instructions
Collection Instructions:
Additional Information:
- Centrifuge and separate cells after clot formation and within 4 hours of collection.
Additional Information:
- Specimens from patients receiving anticoagulant or thrombolytic therapy may take longer to complete their clotting processes. Fibrin clots may form in these sera and the clots could cause erroneous test results.
Transport Container
Plastic vial
Specimen Stability
Room temperature: Not defined
Refrigerated: 1 week
Frozen: 2 weeks
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Unlabeled, mislabeled, wrong tube type, hemolyzed, visually lipemic, QNS, exceeds specimen stability requirements.
Methodology
Immunoturbidimetric
Setup Schedule
Daily
Report Available
Same day
Limitations
Samples containing paraproteins (abnormal monoclonal antibodies) may interfere with test results. Samples with elevated total protein concentrations or samples from patients with suspected paraproteinemia can be screened using other methods such as protein electrophoresis.
Reference Range
Male
0 - 1 year: 0 - 300 mg/dL
1 - 12 year: 3 - 270 mg/dL
12 - 60 years: 40- 258 mg/dL
>60 years: 40 - 268 mg/dL
Female
0 - 1 year: 0 - 235 mg/dL
1 - 12 year: 11 - 220 mg/dL
12 - 60 years: 35 - 250 mg/dL
>60 years: 63 - 273 mg/dL
0 - 1 year: 0 - 300 mg/dL
1 - 12 year: 3 - 270 mg/dL
12 - 60 years: 40- 258 mg/dL
>60 years: 40 - 268 mg/dL
Female
0 - 1 year: 0 - 235 mg/dL
1 - 12 year: 11 - 220 mg/dL
12 - 60 years: 35 - 250 mg/dL
>60 years: 63 - 273 mg/dL
Clinical Significance
Haptoglobin is a protein synthesized in the liver that binds with the globin α‑chains of hemoglobin A, F, S, or C. The haptoglobin-hemoglobin complex is rapidly removed from circulation by the reticuloendothelial system to prevent/minimize hemoglobin loss and to conserve iron.
Indications for haptoglobin quantitation include: anemia or other indicators of possible hemolysis; pregnancy-induced hypertension; transfusion reactions. Decreased levels of haptoglobin are most frequently associated with conditions of increased intravascular hemolysis or hemoglobin turnover, such as hemolytic anemias, intravascular hemolytic transfusion reactions, and malaria. Elevated levels of haptoglobin are most frequently associated with acute phase reactions involving tissue infection, surgery, trauma, or necrosis). Corticosteroid therapy and biliary obstruction can also cause elevation.
Indications for haptoglobin quantitation include: anemia or other indicators of possible hemolysis; pregnancy-induced hypertension; transfusion reactions. Decreased levels of haptoglobin are most frequently associated with conditions of increased intravascular hemolysis or hemoglobin turnover, such as hemolytic anemias, intravascular hemolytic transfusion reactions, and malaria. Elevated levels of haptoglobin are most frequently associated with acute phase reactions involving tissue infection, surgery, trauma, or necrosis). Corticosteroid therapy and biliary obstruction can also cause elevation.
Performing Laboratory
Inova Laboratories
2832 Juniper Street
Fairfax, VA 22031
Last Updated: March 28, 2023
Last Review: N. Wolford, March 28, 2023