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Gentamicin, Random
Test CodeGENTR
Alias/See Also
Epic: LAB27
Preferred Specimen
Specimen Type: Serum
Collection Container: Serum gel
Specimen Volume: 3 mL
Minimum Volume
0.2 mL
Other Acceptable Specimens
Collection Container: Red top
Instructions
Collection Instructions:
Additional Information:
- Centrifuge and separate cells after clot formation and within 4 hours of collection.
Additional Information:
- Provide date and time of last dose.
Transport Container
Plastic vial
Specimen Stability
Room temperature: Undefined
Refrigerated: 7 days
Frozen: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Unlabeled, mislabeled, wrong tube type, QNS, severely (grossly) hemolyzed samples, and any sample from which the lipid layer has not been removed.
Methodology
Chemiluminescent Microparticle Immunoassay (CMIA)
Setup Schedule
Daily
Report Available
Same day
Reference Range
Gentamicin, Peak
Therapeutic: 4.0 - 12.0 μg/mL
Gentamicin, Trough
Therapeutic: 1.2 - 2.0 μg/mL
Therapeutic: 4.0 - 12.0 μg/mL
Gentamicin, Trough
Therapeutic: 1.2 - 2.0 μg/mL
Clinical Significance
Gentamicin is an aminoglycoside antibiotic which exhibits high potency and a broad spectrum bacterial action against both gram-negative and gram-positive organisms. It exhibits a narrow therapeutic index which makes its use hazardous, especially in patients with impaired renal function. In addition, the dose-serum level profile curve of gentamicin is unpredictable, both in terms of peak-serum levels and elimination half-life from plasma. Gentamicin is used in the treatment of serious infections involving aminoglycoside-sensitive organisms. Monitoring gentamicin concentration in serum or plasma, along with careful clinical assessment, is the most effective means of ensuring adequate therapy.
Performing Laboratory
Inova Laboratories
2832 Juniper Street
Fairfax, VA 22031
Last Updated: July 12, 2023
Last Review: N. Wolford, July 12, 2023