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Ceruloplasmin
Test CodeCERUL
Alias/See Also
Epic: LAB703
Preferred Specimen
Specimen Type: Serum red
Collection Container: Red top
Specimen Volume: 3 mL
Minimum Volume
0.25 mL
Instructions
Collection Instructions:
- Centrifuge and separate cells after clot formation and within 4 hours of collection.
- Aliquot serum into a plastic vial. Do not transport red top tube to the lab.
- Specimens from patients receiving anticoagulant or thrombolytic therapy may take longer to complete their clotting processes. Fibrin clots may form in these sera and the clots could cause erroneous test results.
Transport Container
Plastic vial
Specimen Stability
Room temperature: 8 days
Refrigerated: 14 days
Frozen: 3 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Unlabeled, mislabeled, wrong tube type, hemolyzed, visually lipemic, QNS, exceeds specimen stability requirements, gel serum, gel tubes.
Methodology
Turbidimetric/Immunoturbidimetric
Setup Schedule
Daily
Report Available
Same day
Limitations
No prozone effect was observed up to a concentration of 485 mg/dL.
The Ceruloplasmin assay is not affected by the presence of bilirubin up to 66 mg/dL, hemoglobin up to 500 mg/dL, intralipid up to 1000 mg/dL, and rheumatoid factor up to 100 IU/mL.
Reference Range
20 - 60 mg/dL
Clinical Significance
Ceruloplasmin determination is useful in cases of central nervous system diseases of obscure etiology. Low levels of ceruloplasmin occur in Menkes’ syndrome, nephrotic syndromes and in some cases of advanced liver diseases. High levels of ceruloplasmin occur in a variety of neoplastic and inflammatory states.
Performing Laboratory
Inova Laboratories
2832 Juniper Street
Fairfax, VA 22031
Last Updated: April 11, 2023
Last Review: N. Wolford, March 27, 2023