Cyclosporine

Test Code

CYCL

Alias/See Also

Epic: LAB874

CSA Level
Gengraf
Neoral
Sandimmune (Cyclosporine)

Preferred Specimen

Specimen Type: Whole blood EDTA
Collection Container: Lavender top (EDTA)
Specimen Volume: 3 mL

Minimum Volume

0.5 mL

Instructions

Do not centrifuge
Send whole blood specimen in original tube. Do not aliquot.

Specimen Stability

Room temperature: Not applicable
Refrigerated: 7 days
Frozen: >7 days

Avoid multiple freeze/thaw cycles

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Unlabeled, mislabeled, wrong tube type, clotted, QNS, exceeds specimen/stability requirements.

Setup Schedule

Daily

Report Available

1 day

Limitations

The concentration of cyclosporine in a given specimen determined with assays from different manufacturers can vary due to differences in assay methods and reagent specificity. Immunoassays are nonspecific and can cross-react with metabolites. When elimination of cyclosporine is impaired cyclosporine metabolites may accumulate. The reported concentration of cyclosporine may be affected. In such cases, the use of LC/MS/MS should be considered.
Specimens containing HAMA (human anti-mouse antibodies) may produce anomalous values when tested with this assay.
Heterophilic antibodies in human serum can react with reagent immunoglobulins, interfering with in vitro immunoassays.

Reference Range

See laboratory report

Clinical Significance

Cyclosporine is a cyclic undecapeptide of fungal origin and a potent immunosuppressant. It is used as a primary agent during immunosuppressive therapy for heart , liver and kidney transplants. Assessment of cyclosporine concentrations in blood aids in adjusting patients’ dosage and avoids cyclosporine under dosage inefficacy and over dosage toxicity. The use of cyclosporine is associated with serious toxic side effects, primarily nephrotoxicity and hepatotoxicity.

Performing Laboratory
Inova Laboratories
2832 Juniper Street
Fairfax, VA 22031

Last Updated: April 7, 2023
Last Review: N. Wolford, March 6, 2023

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.