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Cardiolipin Antibody (IgM)
Test CodeCPT Codes
<p>86147</p>
Preferred Specimen
Specimen Type: Citrated Plasma
Collection Container/Type
Preferred: Light-blue top (3.2% sodium citrate)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
- Centrifuge specimen and aliquot plasma into a plastic vial.
Specimen Type: Serum
Collection Container/Type
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
-
Centrifuge and separate cells after clot formation and within 4 hours of collection.
-
Aliquot serum into a plastic vial.
Minimum Volume
0.5 mL
Other Acceptable Specimens
Transport Temperature
Specimen Stability
Room temperature: 4 days
Refrigerated: 7 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Grossly lipemic
Methodology
Immunoassay (IA)
Setup Schedule
Tuesday - Saturday
Report Available
Next day
Reference Range
Cardiolipin Antibody IgM
| ≤12 MPL | Negative |
| 13-20 MPL | Indeterminate |
| 21-80 MPL | Low to medium positive |
| >80 MPL | High positive |
Clinical Significance
Cardiolipin antibodies (CA) are seen in a subgroup of patients with autoimmune disorders, particularly Systemic Lupus Erythematosus (SLE), who are at risk for vascular thrombosis, thrombocytopenia, cerebral infarct and/or recurrent spontaneous abortion. Elevations of CA associated with increased risk have also been seen in idiopathic thrombocytopenic purpura, rheumatoid and psoriatic arthritis and primary Sjögren's syndrome.
Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153
Last Updated: February 22, 2012