Hu Antibody Screen with Reflex to Titer and Western Blot

Test Code

HUABS

CPT Codes
86255

Includes

If Hu Antibody Screen, IFA is positive, then Hu Antibody, WB will be performed at an additional charge (CPT code(s): 84181).
If Hu Antibody, WB is positive, then Hu Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

Preferred Specimen

1 mL serum

Minimum Volume

0.2 mL

Instructions

A fasting sample is required.

Transport Container

Transport tube

Transport Temperature

Room tmperature

Specimen Stability

Room tmperature: 7 days Refrigerated: 14 days Frozen: 21 days

Methodology

Immunofluorescence Assay (IFA) • Western Blot (WB)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon, Wed, Fri; Report available: 4 days

Reference Range

Hu Ab Screen, IFA	Negative
Hu Ab, WB	Negative
Hu Ab Titer	<1:40

Clinical Significance

Paraneoplastic Syndrome involves non-metastatic systemic effects that accompany malignant disease. Antineuronal Nuclear Antibody (Anti-Hu) is found in 5-10% of patients with small cell carcinoma of the lung. Anti-Hu is associated with subacute syndrome of encephalomyeloradiculopathy, sensory neuropathy, and autoimmune neuropathy, predominantly affecting the gastrointestinal tract.

Performing Laboratory
Quest Diagnostics Nichols Inst San Juan Capistrano 33608 Ortega Highway San Juan Capistrano, CA 92675

Last Updated: February 23, 2012

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.