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Protein S Antigen, Total and Free
Test CodeCPT Codes
85305, 85306
Preferred Specimen
2 mL platelet-poor plasma collected in a 3.2% sodium citrate (light blue-top) tube
Minimum Volume
1mL
Instructions
Transport Container
Plastic screw-cap vial
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable Refrigerated: Unacceptable Frozen -20C: 30 days Frozen -70C: 1 year
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis
Methodology
Immunoturbidimetric
Setup Schedule
Set up: Tues-Sat p.m.; Report available: Next day
Limitations
Protein S Antigen, Total: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: no effect to decrease; Heparin (UFH or LMWH): no effect; Dabigatran or Argatroban (Thrombin Inhibitors): no effect; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.
Protein S Antigen, Free: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Warfarin: decrease; Heparin (UFH or LMWH): no effect; Dabigatran or Argatroban (Thrombin Inhibitors): no effect; Rivaroxaban or Apixaban (Factor Xa Inhibitors): no effect.
Reference Range
Protein S Antigen, Total | 70-140 % normal |
Protein S Antigen, Free | |
Male | 57-171 % normal |
Female | 50-147 % normal |
Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153
Last Updated: February 23, 2012