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Cholinesterase, RBC and Plasma
MessageDraw two lavender-top (EDTA) tubes of whole blood. Spin one tube to separate plasma. Pipette plasma into plastic aliquot tube (Label this tube as Plasma).
Send one 5 mL refrigerated uncentrifuged whole blood (4 mL minimum) and 1 mL refrigerated plasma (0.5 mL minimum). Do not send packed cells. Do not send one tube of whole blood.
Plasma cholinesterase results, as well as the calculated RBC cholinesterase results, are not accurate if plasma sample is not separated from the RBCs in a timely manner.
Test Code
Alias/See Also
RBC Cholinesterase
LAB13443
CPT Codes
82480, 82482
Preferred Specimen
1 mL plasma and 5 mL whole blood
Minimum Volume
Plasma: 0.5 mL Whole blood: 4 mL
Instructions
Send one 5 mL refrigerated uncentrifuged whole blood (4 mL minimum) and 1 mL refrigerated plasma (0.5 mL minimum).
Do not send packed cells. Do not send only one tube of whole blood.
Plasma cholinesterase results, as well as the calculated RBC cholinesterase results, are not accurate if plasma sample is not separated from the RBC's in a timely manner.
Hemolyzed plasma samples are not acceptable. Hemolysis can lead to apparent increases in plasma cholinesterase activity, and could mask an enzyme deficiency.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 24 hours Refrigerated: 7 days Frozen: Unacceptable
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Lipemia • Received room temperature • Received frozen • Receipt of only a single tube of whole blood
Methodology
Kinetic Spectrophotometric (KS)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Mon-Fri a.m
Report Available
Next day
Limitations
Reference Range
Cholinesterase, RBC 9572-15031 IU/L Cholinesterase, Plasma Male 3334-7031 IU/L Female 2504-6297 IU/L
Clinical Significance
Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153
Last Updated: February 1, 2012