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Osteocalcin, N-MID
MessageAllow blood to clot at room temperature (20-26° C) and centrifuge immediately to separate the serum from the cells. Freeze as soon as possible.
Test Code
OSTEO
Alias/See Also
LAB1060
CPT Codes
83937
Preferred Specimen
1 mL serum
Patient Preparation
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Minimum Volume
0.5 mL
Instructions
Allow blood to clot at room temperature (20-26° C) and centrifuge immediately to separate the serum from the cells. Freeze as soon as possible.
Transport Container
Plastic screw-cap vial
Transport Temperature
Frozen
Specimen Stability
Room temperature: Unacceptable Refrigerated: 24 hours Frozen: 21 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Hemolysis • Heat inactivated specimens • Specimens stabilized with azide • Patient administered with biotin within 8 hours
Methodology
Electrochemiluminescence (ECLIA)
Setup Schedule
Mon-Fri am
Report Available
Next day
Reference Range
Pediatrics: 5-9 years: 47-142 ng/mL
10-13 years: 49-167 ng/mL
14-17 years: Males: 26-203 ng/mL
Females: 14-85 ng/mL
Adults: Males: 9-38 ng/mL
Females: 8-32 ng/mL
Clinical Significance
Osteocalcin, the most abundant non-collagen protein in bone matrix, is a bone-specific, calcium binding protein. Serum osteocalcin levels are related to the rate of bone turnover in various disorders of bone metabolism, e.g., osteoporosis, primary and secondary hyperparathyroidism, and Paget's disease.
Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153
Last Updated: July 21, 2017