Endomysial Antibody Screen (IgA) with Reflex to Titer

Test Code

EDARR

Alias/See Also

LAB3094

CPT Codes
<p>86231</p>

Includes

If Endomysial Antibody (IgA) Screen is positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).

Preferred Specimen

Specimen Type: Serum

Collection Container/Type

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Minimum Volume

0.3 mL

Transport Container

Plastic screw-cap vial

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 7 days

Refrigerated: 21 days

Frozen: 21 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis • Grossly lipemic

Methodology

Immunofluorescence Assay (IFA)

Setup Schedule

Set up: Tues-Sat; Report available: Next day

Report Available

Next day

Reference Range

Endomysial Antibody (IgA)	Negative
Endomysial Antibody Titer	<1:5

Clinical Significance

The presence of anti-endomysial (EMA) IgA antibodies has been shown to correlate with gluten-sensitive enteropathy such as celiac disease (CD) and dermatitis herpetiformis (DH). EMA is detected primarily by IFA, using monkey esophagus as a substrate and observing fluorescence of the endomysial lining. Patients with CD and DH can also demonstrate antibodies to reticulin and gliadin, though EMA-IgA seems to be the most specific marker (specifically 94-100%).

Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153

Last Updated: February 22, 2012

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.