Chromosome Analysis, Tissue

Test Code

CHT

CPT Codes
88233, 88262

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Preferred Specimen

2×3 mm tissue

Minimum Volume

2×3 mm

Other Acceptable Specimens

Tissue collected in sterile saline, in a sterile leak-proof container

Instructions

Patient clinical history/reason for referral required with test order.

See Genetics Specimen Collection Section for detailed specimen instructions.

Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not freeze. Do not reject.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: See instructions Refrigerated: See instructins Frozen: See instructions

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Formalin-fixed

Methodology

Karyotype • Microscopy • Tissue Culture

Setup Schedule

Set up: Daily; Report available: 15 days

Reference Range

See Laboratory Report

Clinical Significance

Chromosome analysis of products of conception (POC) can detect fetal chromosome abnormalities, which are associated with approximately one-half of all first trimester spontaneous abortions. Chromosome testing on fibroblasts obtained from a tissue biopsy is performed to investigate tissue specific mosaicism not present in blood lymphocytes. Fresh cells from tissue biopsies obtained postmortem may still be suitable for chromosome analysis when the patient's blood is not available or viable. If chromosome analysis is unsuccessful, please contact the laboratory genetic counselor at 1-866-GENEINFO (1-866-436-3463) to discuss the option of adding chromosomal microarray (CMA) testing.

Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153

Last Updated: February 22, 2012

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.