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Cryptococcal Antigen, Latex Screen with Reflex to Titer
Test CodeCRYPA
Alias/See Also
LAB3059
CPT Codes
86403
Includes
If Cryptococcal Antigen Screen is Detected, then Cryptococcal Antigen, Latex Titer will be performed at an additional charge (CPT code(s): 86406).
Preferred Specimen
1 mL CSF collected in a sterile, leakproof container . 2 mL serum collected in a serum separator tube (SST)
Minimum Volume
0.5 mL
Instructions
Centrifuge serum specimens within 1 hour of collection. Transfer serum to clean, plastic, screw-capped vial(s). Refrigerate samples and transport on refrigerant coolant, or, freeze samples and transport on dry ice to the laboratory.
Transport Container
CSF: Sterile screw-cap vial
Serum: Plastic screw-cap vial
Transport Temperature
Serum from red-top tube (no gel): Refrigerated or frozen
Serum Separator Tube (SST®): Refrigerated (cold-packs)
CSF: Refrigerated (cold-packs) or frozen
Specimen Stability
Room temperature: Unacceptable Refrigerated: 7 days Frozen: 60 days
Methodology
Latex Agglutination (LA)
Setup Schedule
Set up: Daily p.m. (eveninng, night shift); Report available: Next day
Limitations
Patients with capnocytophaga canimorsus and tichosporon beigelli infections may test falsely-positive.
Reference Range
Not detected
Clinical Significance
The encapsulated soil yeast Cryptococcus neoformans causes Cryptococcosis. Pulmonary infection is acquired by inhalation of the organism and is usually subclinical in the immunocompetent host. Dissemination may occur in an immunocompromised patient, often to the meninges.
Performing Laboratory
Quest Diagnostics Nichols Institute 14225 Newbrook Drive Chantilly, VA 20153
Last Updated: February 22, 2012